Multiple Coupling of Human D5 Dopamine Receptors to Guanine Nucleotide Binding Proteins GS and Gz
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چکیده
منابع مشابه
Gz, a guanine nucleotide-binding protein with unique biochemical properties.
Cloning of a complementary DNA (cDNA) for Gz alpha, a newly appreciated member of the family of guanine nucleotide-binding regulatory proteins (G proteins), has allowed preparation of specific antisera to identify the protein in tissues and to assay it during purification from bovine brain. Additionally, expression of the cDNA in Escherichia coli has resulted in the production and purification ...
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Members of the G protein superfamily contain nucleotide-dependent switches that dictate the specificity of their interactions with binding partners. Using a sequence-based method termed statistical coupling analysis (SCA), we have attempted to identify the allosteric core of these proteins, the network of amino acid residues that couples the domains responsible for nucleotide binding and protei...
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Hormones and most drugs initiate their biological actions by interacting with receptor macromolecules in or on cells. Of the receptors which are located in the plasma membranes of cells, many are coupled to specific effector molecules via intermediary coupling proteins. These are termed “G”-proteins, because they bind and hydrolyze the guanine nucleotide, GTP (1). Among the biological agents wh...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2002
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.1998.70062459.x